Jamie Spangler

Jamie Spangler

Assistant Professor


Molecular engineering, Immunoengineering, cancer immunotherapy, infectious diseases, autoimmune disorders, transplantation medicine, neurological disorders, age-related macular degeneration

Assistant Professor, Biomedical Engineering, and Chemical & Biomolecular Engineering

Leveraging cutting-edge technologies in structural biology and molecular design, we are pioneering a unique structure-based engineering approach to elucidate the determinants of protein activity to inform therapeutic development. We are particularly interested in engineering immune proteins, such as cytokines, growth factors, and antibodies, to bias the immune response for targeted disease treatment.

Featured article

Researchers enhance the function of natural proteins using ‘protein Legos’

Johns Hopkins engineers have helped develop and characterize an artificial protein that triggers the same response in the human body as its natural counterpart—a breakthrough that not only has the potential to facilitate the design of drugs to accelerate healing but also sheds light on the mechanisms behind various diseases.

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Q&A with Jamie Spangler

Jamie Spangler is an assistant professor in the Department of Biomedical Engineering, with a joint appointment in the Department of Chemical and Biomolecular Engineering, at Johns Hopkins University. Through her pioneering research in the fields of immunoengineering and biomolecular engineering, Spangler aims to expand the repertoire of protein therapeutics for treating disease. Her current work focuses on redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs.

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