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The Search for Better Bone Replacement: 3-D Printed Bone with Just the Right Mix of Ingredients

TO MAKE A GOOD FRAMEWORK FOR FILLING IN MISSING BONE, MIX AT LEAST 30 PERCENT PULVERIZED NATURAL BONE WITH SOME SPECIAL MAN-MADE PLASTIC AND CREATE THE NEEDED SHAPE WITH A 3-D PRINTER. THAT’S THE RECIPE FOR SUCCESS REPORTED BY RESEARCHERS AT THE JOHNS HOPKINS UNIVERSITY IN A PAPER PUBLISHED APRIL 18 ONLINE IN ACS BIOMATERIALS SCIENCE & ENGINEERING.

A Sample 3-D Printed Scaffold That Matches The Lower Jaw Of A Female Patient.

Each year, the Johns Hopkins scientists say, birth defects, trauma or surgery leave an estimated 200,000 people in need of replacement bones in the head or face. Historically, the best treatment required surgeons to remove part of a patient’s fibula (a leg bone that doesn’t bear much weight), cut it into the general shape needed and implant it in the right location. But, according to Warren Grayson, Ph.D., associate professor of biomedical engineering at the Johns Hopkins University School of Medicine and the report’s senior author, the procedure not only creates leg trauma but also falls short because the relatively straight fibula can’t be shaped to fit the subtle curves of the face very well.

Read the full article.

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John’s Story: Tracheal Stenosis

“MY WIFE AND I USE IT AS A LITTLE VACATION,” JOHN SMILES, REFERRING TO HIS TRIPS TO THE JOHNS HOPKINS HOSPITAL.

The Complex Airway Clinic Team Composed Of Alexander Hillel, M.D., David Feller-Kopman, M.D., And Richard Battafarano, M.D., Ph.D.

A patient of otolaryngologist Alexander Hillel, M.D., John has traveled to Baltimore from his Peterstown, West Virginia, home seven times. But Baltimore is more than a makeshift vacation spot for John — it’s where he took his first full breath.

Before coming to Johns Hopkins, John wasn’t sleeping well. When he did eventually fall asleep, his wife and children would watch him, counting the seconds between each breath he took — 35, 36, 37, 38. The breathless spells were broken by an eruption of gasps and choking sounds that alarmed John’s family and disrupted his sleep.

Read the full article on https://www.hopkinsmedicine.org.

Categories News

Cancer Research: Your Cells’ Sugar Diet

FOR KEVIN YAREMA, RESEARCH IS SWEET.

Kevin Yarema Has Focused Much Of His Efforts On Metabolic Glycoengineering — The Ability To Manipulate Cells’ Natural Process Of Ingesting Sugars And Converting Them Into Complex Sugar Structures That Cover The Cell Surface.

Yarema, an associate professor in Biomedical Engineering, has focused much of his efforts on metabolic glycoengineering — the ability to manipulate cells’ natural process of ingesting sugars and converting them into complex sugar structures that cover the cell surface.

“Cells can change these sugars depending on what they’re doing,” Yarema says. Similar to how people change clothes for a wedding versus playing rugby, he says, cells constantly change their sugar coatings. Cancer cells, for example, are able to use about 200 times more glucose than normal cells, which often results in different sugars displayed on their surfaces than healthy cells.

Read the full article on https://www.bme.jhu.edu/news-events.