Joshua Doloff

Assistant Professor, Biomedical Engineering, Materials Science & Engineering

Our mission is to better understand what happens when therapeutics–whether biologic or synthetic in origin–are introduced into the body. Of key importance is how the host immune system perceives them and how it behaves toward them. We use systems biology and synthetic biology approaches to elucidate these complex tissue dynamics and generate improved therapies.

Featured articles

Study Points a way to Better Implants

Medical devices implanted in the body for drug delivery, sensing, or tissue regeneration usually come under fire from the host’s immune system. Defense cells work to isolate material they consider foreign to the body, building up a wall of dense scar tissue around the devices, which eventually become unable to perform their functions.

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https://www.hopkinsmedicine.org/news/newsroom/news-releases/study-suggests-that-smoother-silicone-breast-implants-reduce-severity-of-immune-system-reactions

https://www.bme.jhu.edu/news-events/news/new-immune-model-sheds-light-on-implant-rejection/