The Kalhor lab seeks to understand how genetic and environmental factors alter cell fate in development to affect adult phenotype or cause diseases. We develop: (A) molecular technologies for mapping and engineering cell fate decisions, (B) spatial and single-cell sequencing strategies to characterize the spatiotemporal changes of tissues during development, and (C) computational methods to reconstruct developmental processes by integrating genomically recorded and spatially extracted information. These approaches synergize with the foundational pillars of TTEC to characterize and engineer cell and tissue behavior to advance healthy aging, precision medicine, and disease modeling.
