My research focuses on the development and application of engineered biomaterials and human stem cell/tissue engineering technologies, including microfabricated tissues such as organ chips, organoids, and bio-printed tissues, for disease modeling, drug development, and precision medicine. By integrating AI and digital organ twin models with experimental human mini-organ twin models, we aim to develop more predictive human preclinical models for drug discovery and precision medicine. Additionally, my work integrates state-of-the-art multi-scale biomanufacturing techniques with advanced 3D tissue-engineered models of human disease, incorporating biosensors and AI/ML-enabled biosystems for clinically relevant functional analyses. The ultimate goal of my research is to better understand complex human disease biology in response to microenvironmental cues in normal, aging, and disease states, gaining new mechanistic insights into the control of cell-tissue structure and function, and developing multi-scale regenerative technologies for improving human health. I believe these efforts directly support TTEC’s mission to advance transformative technologies in the area of translational tissue engineering.”
