My research focuses on the development of biodegradable materials for bone fixation, bone defects, arterial stents, and drug delivery with a particular emphasis on orthopedic applications and biodegradable Mg alloys.
Reza Kalhor
The Kalhor lab seeks to understand how genetic and environmental factors alter cell fate in development to affect adult phenotype or cause diseases. We develop: (A) molecular technologies for mapping and engineering cell fate decisions, (B) spatial and single-cell sequencing strategies to characterize the spatiotemporal changes of tissues during development, and (C) computational methods to reconstruct developmental processes by integrating genomically recorded and spatially extracted information. These approaches synergize with the foundational pillars of TTEC to characterize and engineer cell and tissue behavior to advance healthy aging, precision medicine, and disease modeling.
Rachel Karchin
The Karchin lab is developing on AI approaches to neoantigen prediction, including its relevance for vaccine design, TCR repertoire modeling, and spatial approaches to tumor and TCR clonal evolution. These projects overlap with TTEC’s interests in Immuno engineering and single cell/spatial transcriptomics.
Luo Gu
The Gu laboratory studies how cells sense and respond to the mechanical and biochemical cues from their microenvironment. The findings from these studies are then used to design and create new biomaterials that provide desirable signals to direct cell behavior and function for applications in tissue engineering, cell therapy manufacturing, and immunoengineering.
Laura Ensign
Dr. Ensign’s lab works broadly within nanomedicine and the development of therapeutics that provide sustained and effective treatment. Recent efforts aim to apply the principles of nanomedicine to provide various supportive approaches for enhancing cell and tissue regeneration, as well as utilizing nanomedicine for characterizing disease processes.