Affilliated Faculty

Patrick Byrne

Dr. Byrne’s research efforts focus on three areas:
Facial paralysis is a particular area of interest. He and his colleagues have investigated new ways to help the facial nerve regenerate, and have contributed new techniques to help restore facial symmetry and the ability to smile.
Reconstruction after cancer treatment – Dr. Byrne investigates cutting edge techniques to reconstruct the face after cancer treatment.|
Rhinoplasty has led him to research the effects of various rhinoplasty maneuvers on the shape and function of the nose.

Lab page:   http://www.hopkinsmedicine.org/otolaryngology/our_team/faculty/byrne.html

 

M. Valerie Canto-Soler

Dr. Canto-Soler’s research focuses on the study of the mechanisms that regulate the behavior of retinal cells in both normal and diseased conditions.  Currently, her research interests are focused on two main, highly complementary areas:  The study of the mechanisms that control retinal progenitor cell differentiation during normal development., The use of human “induced pluripotent stem cells” (iPS) to study the mechanisms leading to retinal dystrophies and their potential clinical application in therapies involving cell transplantation.

Lab page:  http://www.hopkinsmedicine.org/wilmer/research/retdeg.html

 

Thomas L. Clemens
Lewis Cass Spencer Professor of Orthopaedic Surgery

The overall goal of our research is to identify of the cellular and molecular mechanisms that control skeletal development and repair. Cell and mouse models with specific alterations in these pathways are being used to study the role of growth factors and hypoxia inducible factors during bone development and following skeletal injury.

Lab page:  http://www.hopkinsortho.org/tclemens.pdf

 

Sharon Gerecht

Gerecht studies how changes in micro- and nano-scale environment can affect the growth and function of stem cells with focus on vascular development and regeneration. Gerecht is looking at ways to direct stem cell differentiation by engineering different chemical, mechanical and physical environments upon which the cells grow. This may have implications on how stem cells could be used in medical therapy.

Lab page: http://www.jhu.edu/chembe/gerecht/

 

Ahmet Hoke 

My laboratory is interested in basic biology of peripheral axons and Schwann cells and disorders affecting the peripheral nervous system. We use in vitro and in vivo models of peripheral neuropathies (HIV-associated sensory neuropathies, chemotherapy-induced toxic neuropathies and diabetic neuropathy) to study the mechanism of axonal damage and identify therapeutic targets for drug development. In addition, we study mechanisms of axonal degeneration and regeneration in traumatic injury and develop nanofiber based nerve graft conduits. We utilize engineered stem cells as therapeutic gene delivery tools to promote axonal regeneration in chronically denervated nerves as seen traumatic injuries and many degenerating disorders of the peripheral nervous system such as amyotrophic lateral sclerosis and inherited neuropathies.

 

 

Dara Kraitchman 

Kraitchman’s research interests are in using non-invasive imaging for the study of regenerative medicine.  Her lab focuses on minimally invasive techniques to delivery and track stem cells with a concentration on the cardiovascular system.  To enhance cell engraftment, she collaborates with the Mao lab to develop novel methods to provide immunoprotection that also assist with providing substrates/tissue matrices for cell growth.  She is the cardiovascular interventional section head in the Division of MR research in the Department of Radiology.

Department site:  http://www.mri.jhu.edu/DivMRRes/kraitchman.htm

 

Gabsang Lee

The Lee lab focuses on neural crest biology using human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC). Neural crest cells emerge in early development and they are a multipotent population that can give rise to more than 30 different cell types. To understand the neural crest specification process, he will use a genetic reporter system in hESCs to isolate neural crest sub-lineages to get purified cell types, which will be used to study development and disease progression.

Lab page: http://neuroscience.jhu.edu/GabsangLee.php

 

Aleksander S. Popel

Research interests:   Angiogenesis; Microcirculation; Signal Tramsdiction; Systems Biology; Computational Biology and Medicine; In Vitro and In Vivo Experiments; Biological Mechanics and Molecular Transport; Cancer, Cardiovascujlar Disease

Lab page: http://www.jhu.edu/apopel/

 

Jonathan Schneck

Jonathan Schneck (Professor of Pathology, Medicine and Oncology) received his MD-PhD in Immunology from the Albert Einstein College of Medicine. After completing his degree, Dr. Schneck trained in Pediatrics at the Children’s Hospital National Medical Center in Washington DC. From there he went to the National Institute of Allergy and Immunology at the NIH in Bethesda and did his postdoctoral training at the Laboratory of Immunology. He joined the faculty at JHMI in 1990 as a junior faculty and is currently a Professor in Pathology, Medicine and Oncology. His lab is focused on T cell immunology in the Department of Pathology. When not in lab, Dr. Schneck is a family man with 5 children. Dr. Schneck enjoys skiing and photography.

Lab page:  http://pathology.jhu.edu/schnecklab/index.cfm

 

Peter Searson

Searson’s research interests include the synthesis and characterization of nanostructured materials, electrodeposition and patterning, and applications for nanotechnology in biology and medicine. Peter led the launch of the Johns Hopkins University’s Institute for Nanobiotechnology in 2006 and currently serves as the Institute’s director.

Lab page: http://www.jhu.edu/searson/

 

Hongjun Song

We are interested in understanding novel mechanisms regulating structural and functional plasticity in the mature mammalian center nervous system.  There are two major topics in the laboratory: one is on adult mammalian neural stem cells and neurogenesis; and the other is on epigenetic DNA modifications in the mature nervous system.

Lab page: http://www.neuroscience.jhu.edu/HongjunSong.php

 

Kathryn Wagner 
Associate Professor of Neurology and Neuroscience

Dr. Wagner obtained her undergraduate degree from Yale University, graduating summa cum laude with honors in biology. She participated in the NIH-funded medical scientist training program and obtained her medical and doctoral degrees at Johns Hopkins. Her thesis work in the laboratory of Richard Huganir, Ph.D., included the original cloning and characterization of the dystrophin-associated protein, dystrobrevin.

Lab page:  http://www.kennedykrieger.org/patient-care/faculty-staff/kathryn-wagner

Jeff Wang

Dr. Wang’s research focuses on the development of new technologies for molecular analysis and biomedical research via advances in micro- and nano-scale sciences. His lab aims to develop new methods, devices and systems with unprecedented performance characteristics, such as sensitivity, specificity, resolution (temporal and/or spatial), multiplexing and throughput to rectify current technological limitations in the molecular study of diseases. By forging long-term collaborations with medical scientists and physicians across various disciplines and by leveraging the engineering innovations in microfluidics, single molecule spectroscopy and functional nanoparticles, his lab is developing genetic and epigenetic biomarker-based diagnostics, prognostics and monitoring for cancer and an array of other diseases.

Lab page: http://www.me.jhu.edu/thwang/

Samuel Yiu 

Dr. Samuel Yiu received a B.A. in Chemistry, a M.S. in Applied Biometry, and the Ph.D. in Physiology Biophysics from the University of Southern California. His M.D. degree was received from the University of Alberta, Canada. Dr. Yiu completed a residency in ophthalmology at Dalhouise University, Canada and completed a postdoctoral fellowship in Cornea/External Diseases and Refractive Surgery at the Doheny Eye Institute.

 

 

 

Leslie Tung
Dr. Tung’s research is focused on cardiac electrophysiology and arrhythmia at a multicellular, syncytial level. His lab uses cell culture models in a manner akin to mathematical models in which elements of the model can be designed, synthesized or controlled. Currently, the lab is investigating basic and translational aspects of heart cells derived from human pluripotent stem cells in two-dimensional monolayers and three-dimensional engineered tissues.

Lab page:  https://sites.google.com/site/jhucbsl/

 

Alexander A. Spector                                                                                                                                                                                                                              Alex Spector

Dr. Spector’s research areas are cell mechanics and biophysics, mechanotransduction, mechanobiology, computational modeling, and design/interpretation of experiments. He focuses on the mathematical modeling of stem cell myogenesis, including the time course of and interaction between the myogenic factors, cell fusion, and the effects of mechanical cues. This research is a collaborative project with Grayson’s lab.

Lab page: http://www.bme.jhu.edu/people/primary.php?id=334