TTEC Seminar Speaker

Monday, June 17, 2013
1:30pm – 2:30pm
Smith Building, ATRIUM (first floor)

Lino Ferreira
Center of Neurosciences and Cell Biology (CNC)/Biocant (Coimbra)

Bioengineering strategies to modulate stem cell differentiation and improve cell engraftment

Lino Ferreira holds a Ph.D. in Biotechnology (2003) from the University of Coimbra (Portugal). He did postdoctoral work at MIT (USA) in the laboratory of Professor Robert Langer in the areas of human embryonic stem cells, micro- and nanotechnologies. He joined the Center of Neurosciences and Cell Biology (CNC, University of Coimbra) and Biocant (Innovation Center, Portugal) in October 2007. He has published more than 60 peer reviewed papers and has 14 issued or pending patents– 7 of which have been licensed to companies in the biomedical industry. He is the director of the Biomaterials and Stem Cell-Based Therapeutics research group and the CNC coordinator of the MIT-Portugal Program. In 2012 he was awarded with a prestigious European Research Council starting grant. The research group aims at generating fundamental and translational knowledge in the intersection of biomaterials with stem cells.

In the first part of my talk, I will cover our recent work in the use of nanomaterials to modulate cells, in particular stem cells. Although initial studies in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of other molecules to modulate cell activity, either in exogenous or endogenous cells. During my presentation I will give some examples of nanomaterials that can be used to manipulate stem cell differentiation either in vitro or in vivo, and to improve cell survival. In the second part of my talk, I will present recent results about the use of stem cells to generate vascular models for toxicity and drug screening analyses.

*Kraehenbuehl, TP, Langer, R*, Ferreira, LS*. “Biomaterials for the self-renewal and differentiation of human pluripotent stem cells”. Nature Methods 2011, 8(9), 731-736.
*Maia, J, Santos, T, Aday, S, Agasse, F, Cortes, L, Malva, JO, Bernardino, L*, Ferreira, L*. “Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles”. ACS Nano 2011, 5(1), 97-106.
*Santos, T, Ferreira, R, Maia, J, Agasse, F, Xapelli, S, Cortes, L, Bragança, J, Malva, JO, Ferreira, L*, Bernardino, L*. “Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain”. ACS Nano 2012, 6(12), 10463-10474. *Authors contributed equally.
*Gomes, RSM, Neves, R, Cochlin, L, Lima, AF, Carvalho, R, Korpisalo, P, Dragneva, G, Turunen, M, Liimatainen, T, Clarke, K, Yla-Herttuala, S, Carr, CA, Ferreira, L. “Nanoparticles for simultaneous cell tracking and pro-survival/angiogenic miRNA delivery in an ischemic animal model”. ACS Nano 2013, 7(4), 3362-3372.