The Regenerative Medicine and Tissue Engineering Symposium – October 7, 2014

The Regenerative Medicine and Tissue Engineering Symposium

co-organized by: Institute for Cell Engineering and

Translational Tissue Engineering Center

October 7, 2014
8:30am – 5:30pm

Mountcastle Auditorium, PCTB

Keynote Speakers:

 Dr. Irv Weismann   Stanford University and

Dr. Arnold Caplan   Case Western Reserve University

Seminar Schedule
Introduction and vision
Ted Dawson, M.D., PhD

Single-cell biology of adult neural stem cells
Hongjun Song

Transdifferentiation in vivo
Erica Matunis

Adult Mesenchymal Stem Cell: The New Medicine
Keynote Speaker, Dr. Arnold Caplan 

Coffee break

MSCs in Bone Remodeling and Osteoarthritis
Xu Cao

Translational Imaging of Transplanted Cells in Vivo
Jeff Bulte

Molecular and cellular mechanisms underlying asymmetric histone inheritance
Xin Chen

Hydrogels to modulate vascular assembly and regeneration
Sharon Gerecht

Generation of multipotent induced neural crest by direct reprogramming of human postnatal fibroblasts
Yong Jun Kim

Lunch and poster viewing

Normal and Neoplastic Stem Cells Keynote speaker
Irv Weisman

dsRNA: a signal for organ regeneration
Luiz Garza

Reconstructive Transplantation: From Scientific Dream to Clinical Reality
Gerald Brandacher

Developmental and Regenerative Biology of Cardiac Progenitor Cells
Chulan Kwon

Coffee break

Modeling the ecosystem of cancer through Experimental Multicellular Niches
Ken Pienta

Pre-clinical and Clinical evidence for the development of a neo-urinary conduit
Trinity Bivalacqua

Genetically Engineering Mesenchymal Stem Cells with Nanoparticles
Alfred Quinones-Hinojosa

Systems Engineering Applied to Advanced Prosthetics
Mike McLoughlin

STORM: Stem Cells and Ocular Regenerative Medicine
Donald Zack

Concluding Remarks
Jennifer Elisseeff/Guo-li Ming

TTEC Seminar Speaker

Monday, June 17, 2013
1:30pm – 2:30pm
Smith Building, ATRIUM (first floor)

Lino Ferreira 
Center of Neurosciences and Cell Biology (CNC)/Biocant (Coimbra)

Bioengineering strategies to modulate stem cell differentiation and improve cell engraftment

Lino Ferreira holds a Ph.D. in Biotechnology (2003) from the University of Coimbra (Portugal). He did postdoctoral work at MIT (USA) in the laboratory of Professor Robert Langer in the areas of human embryonic stem cells, micro- and nanotechnologies. He joined the Center of Neurosciences and Cell Biology (CNC, University of Coimbra) and Biocant (Innovation Center, Portugal) in October 2007. He has published more than 60 peer reviewed papers and has 14 issued or pending patents– 7 of which have been licensed to companies in the biomedical industry. He is the director of the Biomaterials and Stem Cell-Based Therapeutics research group and the CNC coordinator of the MIT-Portugal Program. In 2012 he was awarded with a prestigious European Research Council starting grant. The research group aims at generating fundamental and translational knowledge in the intersection of biomaterials with stem cells.

In the first part of my talk, I will cover our recent work in the use of nanomaterials to modulate cells, in particular stem cells. Although initial studies in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of other molecules to modulate cell activity, either in exogenous or endogenous cells. During my presentation I will give some examples of nanomaterials that can be used to manipulate stem cell differentiation either in vitro or in vivo, and to improve cell survival. In the second part of my talk, I will present recent results about the use of stem cells to generate vascular models for toxicity and drug screening analyses.

*Kraehenbuehl, TP, Langer, R*, Ferreira, LS*. “Biomaterials for the self-renewal and differentiation of human pluripotent stem cells”. Nature Methods 2011, 8(9), 731-736.
*Maia, J, Santos, T, Aday, S, Agasse, F, Cortes, L, Malva, JO, Bernardino, L*, Ferreira, L*. “Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles”. ACS Nano 2011, 5(1), 97-106.
*Santos, T, Ferreira, R, Maia, J, Agasse, F, Xapelli, S, Cortes, L, Bragança, J, Malva, JO, Ferreira, L*, Bernardino, L*. “Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain”. ACS Nano 2012, 6(12), 10463-10474. *Authors contributed equally.
*Gomes, RSM, Neves, R, Cochlin, L, Lima, AF, Carvalho, R, Korpisalo, P, Dragneva, G, Turunen, M, Liimatainen, T, Clarke, K, Yla-Herttuala, S, Carr, CA, Ferreira, L. “Nanoparticles for simultaneous cell tracking and pro-survival/angiogenic miRNA delivery in an ischemic animal model”. ACS Nano 2013, 7(4), 3362-3372.

TTEC Inauguration

TTEC was officially inaugurated in the Smith Building Atrium.  Peter McDonnell, Andy Lee, Elliot McVeigh, and TTEC Director Jennifer Elisseeff spoke about the importance of tissue engineering and regenerative medicine at Johns Hopkins and the exciting new opportunities that will now be available.

International nanobio research opportunity for Hopkins students

Nanobiotechnology in Belgium is great, but their waffles might be better. (Mike Keung 2009)

Belgium is well known for developing many fine things: chocolate…beer…waffles.

Nanobiotechnology also tops the country’s list of research and development activities. Undergraduate and graduate students at Johns Hopkins University now have the chance to apply for a short-term nanobio research program in Belgium hosted by the Johns Hopkins Institute for NanoBioTechnology (INBT).

Applications are now being accepted for INBT’s summer 2012 International Research Experience for Students (IRES) program. The application deadline is March 25, 2012. INBT funds several research internships at IMEC, The Inter-University MircroElectronics Centre, in Leuven, Belgium through the IRES program, funded by the National Science Foundation. Students work on collaborative research projects organized between Hopkins faculty and IMEC researchers at IMEC’s world-class microfabrication facility and learn to design, fabricate and test a wide range of biomedical devices. The internships are for 10 to 12 weeks and include travel expenses, accommodations and a stipend.

The IRES program is open to Johns Hopkins undergraduate and graduate students who are science or engineering majors and have at least one year of research experience. Graduate students should have additional relevant research experience. Students from under-represented racial/minority groups and women in science and engineering are especially encouraged to apply.

To apply for this unique opportunity, send your resume along with a summary of your research experience and the name and contact information of at least one faculty research advisor to Ashanti Edwards at Only U.S. citizens and permanent residents are eligible to apply. A very limited number of IRES positions are available, so don’t wait until the deadline to apply.

If you have additional questions, please contact Ashanti Edwards at or (410) 516-6572 for more information on the application process.

Additional information:

Story by Mary Spiro

Johns Hopkins and UVa co-host 2-day imaging workshop

Learn about state-of-the-art imaging methods at the In Vivo Preclinical Imaging: an Introductory Workshop, March 20-21 at Johns Hopkins University’s School of Medicine Turner Auditorium. Co-hosted by Johns Hopkins University, the University of Virginia and the Society of Nuclear Medicine (SNM), this workshop will bring together gifted lecturers to cover the fundamentals of in vivo small animal imaging.

The workshop will cover an incredible breadth of material of interest and value to physicians, scientists (including postdoctoral fellows and graduate students) and scientific laboratory professionals interested in using molecular imaging for in vivo biomedical applications. Individuals with experience in small animal imaging as well as beginners are welcome. Participants learn the fundamentals of various small animal imaging modalities. A limited number of participants will also have the opportunity to register to attend a half-day, hands on workshop held on the afternoon of the second day, March 21. Registration for this unique opportunity is on first-come first-served, so don’t wait to register.

Speakers will address imaging modalities including MRI and MRS, PET, SPECT, optical imaging (bioluminescence & fluorescence imaging/tomography), ultrasound, x-ray CT, photoacoustic imaging and multimodality imaging. Speakers will also examine instrumentation, acquisition and reconstruction, MR/SPECT/PET imaging probes, targets and applications, small animal handling, techniques for imaging infectious disease models and data analysis.

More information about the workshop, including a full agenda of topics, registration and details about transportation and lodging can be found at the workshop website.