The Regenerative Medicine and Tissue Engineering Symposium – October 7, 2014

The Regenerative Medicine and Tissue Engineering Symposium

co-organized by: Institute for Cell Engineering and

Translational Tissue Engineering Center

October 7, 2014
8:30am – 5:30pm

Mountcastle Auditorium, PCTB

Keynote Speakers:

 Dr. Irv Weismann   Stanford University and

Dr. Arnold Caplan   Case Western Reserve University

Seminar Schedule
Introduction and vision
Ted Dawson, M.D., PhD

Single-cell biology of adult neural stem cells
Hongjun Song

Transdifferentiation in vivo
Erica Matunis

Adult Mesenchymal Stem Cell: The New Medicine
Keynote Speaker, Dr. Arnold Caplan 

Coffee break

MSCs in Bone Remodeling and Osteoarthritis
Xu Cao

Translational Imaging of Transplanted Cells in Vivo
Jeff Bulte

Molecular and cellular mechanisms underlying asymmetric histone inheritance
Xin Chen

Hydrogels to modulate vascular assembly and regeneration
Sharon Gerecht

Generation of multipotent induced neural crest by direct reprogramming of human postnatal fibroblasts
Yong Jun Kim

Lunch and poster viewing

Normal and Neoplastic Stem Cells Keynote speaker
Irv Weisman

dsRNA: a signal for organ regeneration
Luiz Garza

Reconstructive Transplantation: From Scientific Dream to Clinical Reality
Gerald Brandacher

Developmental and Regenerative Biology of Cardiac Progenitor Cells
Chulan Kwon

Coffee break

Modeling the ecosystem of cancer through Experimental Multicellular Niches
Ken Pienta

Pre-clinical and Clinical evidence for the development of a neo-urinary conduit
Trinity Bivalacqua

Genetically Engineering Mesenchymal Stem Cells with Nanoparticles
Alfred Quinones-Hinojosa

Systems Engineering Applied to Advanced Prosthetics
Mike McLoughlin

STORM: Stem Cells and Ocular Regenerative Medicine
Donald Zack

Concluding Remarks
Jennifer Elisseeff/Guo-li Ming

Jordan Green named to the ‘Brilliant Ten’ list

Dr. Green made Popular Science’s annual “Brilliant Ten” list, which puts a spotlight on young scientists who are revolutionizing their fields.

The magazine honored Jordan Green, among “the most inspired young scientists and engineers—researchers whose ideas will transform the future.”

Green, 33, uses tiny, biodegradable particles to teach the immune system to recognize cancer cells. Others have tried this with round particles, but Green decided to make them football-shaped to maximize the surface area available for interacting with immune cells.

When given to mice with skin cancer, the elongated particles reduced tumor growth by an additional 25 percent and the mice lived longer than those that got round particles. Now, researchers in his field know to take shape into account when testing similar therapies.

The “Brilliant Ten” list appears online and in the October edition of Popular Science.

Programming Cancer Cells to Self-Destruct | Science: Out of the Box

NIBIB Bionic Man Goes LIVE

Dr. Elisseeff is happy to announce that the NIBIB Bionic Man, which features her cartilage regeneration research recently published in Science Translational Medicine, January 13, 2013.  The Bionic Man has been completed and now LIVE.

The Bionic Man is an interactive web tool that will be used by students, science enthusiasts, and the general public to learn about innovative technologies being developed by NIBIB-funded researchers.

The Bionic Man








Browse a selection of technologies and interventions being developed by NIBIB supported researchers.

These advancements may one day prevent, heal and cure injuries and diseases.

These advancements may one day prevent, heal and cure injuries and diseases


Congratulations to Xavier Ory

Congrats to Xavier Ory on his prestigious award, Prix de l’Académie des Sciences, for his work during his summer internship in the Elisseeff Lab. Xavier is a student at Ecole Polytechnique in Paris. Xavier will receive his prize during a ceremony to be held on November 26, 2013 at the Académie des Sciences and on December 17, 2013 at the Ecole Polytechnique.


Football-Shaped Particles Bolster The Body’s Defense Against Cancer

Release Date: 10/14/2013
spherical versus football-shaped particles
T-cells (red) are activated more robustly when they interact with artificial antigen-presenting cells (green) that are elongated (right) versus round (left).
Karlo Perica

Researchers at Johns Hopkins have succeeded in making flattened, football-shaped artificial particles that impersonate immune cells. These football-shaped particles seem to be better than the typical basketball-shaped particles at teaching immune cells to recognize and destroy cancer cells in mice.

“The shape of the particles really seems to matter because the stretched, ellipsoidal particles we made performed much better than spherical ones in activating the immune system and reducing the animals’ tumors,” according to Jordan Green, Ph.D., Assistant Professor of Biomedical Engineering at the Johns Hopkins University School of Medicine and a collaborator on this work. A summary of the team’s results was published online in the journal Biomaterials on Oct. 5.


TTEC Seminar Speaker

Monday, June 17, 2013
1:30pm – 2:30pm
Smith Building, ATRIUM (first floor)

Lino Ferreira 
Center of Neurosciences and Cell Biology (CNC)/Biocant (Coimbra)

Bioengineering strategies to modulate stem cell differentiation and improve cell engraftment

Lino Ferreira holds a Ph.D. in Biotechnology (2003) from the University of Coimbra (Portugal). He did postdoctoral work at MIT (USA) in the laboratory of Professor Robert Langer in the areas of human embryonic stem cells, micro- and nanotechnologies. He joined the Center of Neurosciences and Cell Biology (CNC, University of Coimbra) and Biocant (Innovation Center, Portugal) in October 2007. He has published more than 60 peer reviewed papers and has 14 issued or pending patents– 7 of which have been licensed to companies in the biomedical industry. He is the director of the Biomaterials and Stem Cell-Based Therapeutics research group and the CNC coordinator of the MIT-Portugal Program. In 2012 he was awarded with a prestigious European Research Council starting grant. The research group aims at generating fundamental and translational knowledge in the intersection of biomaterials with stem cells.

In the first part of my talk, I will cover our recent work in the use of nanomaterials to modulate cells, in particular stem cells. Although initial studies in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of other molecules to modulate cell activity, either in exogenous or endogenous cells. During my presentation I will give some examples of nanomaterials that can be used to manipulate stem cell differentiation either in vitro or in vivo, and to improve cell survival. In the second part of my talk, I will present recent results about the use of stem cells to generate vascular models for toxicity and drug screening analyses.

*Kraehenbuehl, TP, Langer, R*, Ferreira, LS*. “Biomaterials for the self-renewal and differentiation of human pluripotent stem cells”. Nature Methods 2011, 8(9), 731-736.
*Maia, J, Santos, T, Aday, S, Agasse, F, Cortes, L, Malva, JO, Bernardino, L*, Ferreira, L*. “Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles”. ACS Nano 2011, 5(1), 97-106.
*Santos, T, Ferreira, R, Maia, J, Agasse, F, Xapelli, S, Cortes, L, Bragança, J, Malva, JO, Ferreira, L*, Bernardino, L*. “Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain”. ACS Nano 2012, 6(12), 10463-10474. *Authors contributed equally.
*Gomes, RSM, Neves, R, Cochlin, L, Lima, AF, Carvalho, R, Korpisalo, P, Dragneva, G, Turunen, M, Liimatainen, T, Clarke, K, Yla-Herttuala, S, Carr, CA, Ferreira, L. “Nanoparticles for simultaneous cell tracking and pro-survival/angiogenic miRNA delivery in an ischemic animal model”. ACS Nano 2013, 7(4), 3362-3372.

Congratulations to Stephanie Tzeng

Congrats to Stephany Tzeng, member of the Green Group, on her receipt of the Society For Biomaterials’ 2013 Student Award for Outstanding Research.

Congratulations to Evan Smith

Congratulations to Evan Smith, an Ingenuity Project student working in the Green Group, on winning the Baltimore Science Fair.

New material could help repair damaged cartilage

A jiggly material called hydrogel, similar in texture to Jell-O, may help mend damaged cartilage, keeping joints moving and people active.

The slippery hydrogel can jump-start cartilage growth and reduce pain, compared with the most common procedure now used in surgery, a group of scientists reported Wednesday in the journal Science Translational Medicine.

Read more:

Jordan Green named Maryland Outstanding Young Engineer

TTEC Member Jordan Green was named the Maryland Outstanding Young Engineering (OYE) October 24, 2012.  The award program was established to recognize and celebrate extraordinary contributions of young Maryland scientists and engineers. The award is sponsored by the Maryland Academy of Sciences and conferred by the Maryland Science Center to recognize and encourage the important work of young professional scientists and engineers residing in the State of Maryland and increase public awareness of their accomplishments.  TTEC has a great record with the award with Warren Grayson receiving the 2010 OYE Award!  Congrats to Jordan!